Girls With Type 2 Diabetes at Higher Risk for Ovarian Cysts
New research shows that girls with type 2 diabetes can set themselves up for developing a condition known as polycystic ovary syndrome (PCOS).
PCOS occurs when a woman's ovaries or adrenal glands produce more male
hormones than normal, and its many symptoms include painful cysts on the
ovaries, irregular periods, excessive hair growth, acne, weight gain and
infertility.
Exactly how type 2 diabetes and PCOS
are linked isn’t fully understood yet.
"There's more work to be done to
explore the genetic, epigenetic and environmental factors that can explain this
association," said study author Dr. M. Constantine Samaan. He's an associate
professor of pediatrics at McMaster University and McMaster Children's Hospital
in Hamilton, Ontario, Canada.
Insulin resistance likely plays a
central role in both conditions, Samaan said. When the body doesn't respond
well to insulin, blood sugar can build up in your bloodstream, eventually
leading to type 2 diabetes. Many women with PCOS are also insulin-resistant.
Samaan and his colleagues conducted a
review to get a better handle on the risk of PCOS in girls with type 2
diabetes. Just shy of 20% of 470 girls with type 2 diabetes from six studies
conducted across several countries had PCOS. That rate is at least twice as
high as it is in the general adolescent population, he noted.
"Previously, we knew that some
girls with type 2 diabetes can develop PCOS, and our paper defines the specific
global prevalence of PCOS in type 2 diabetes in girls," Samaan said.
Awareness of PCOS risk is the key, he said. "Girls with type 2 diabetes need to be counseled about the risk of PCOS, and patients need to share information with their providers about irregular periods, acne or excessive hair growth, to allow appropriate investigations and treatments to be implemented," Samaan said.
Dr. Laurie Cohen, chief of the
Division of Pediatric Endocrinology and Diabetes at the Children’s Hospital at
Montefiore in New York City, points out that it's a two-way street when it
comes to type 2 diabetes and PCOS.
"Individuals with PCOS are at
increased risk for metabolic syndrome and type 2 diabetes, so should be
screened for these conditions, and individuals with obesity or type 2 diabetes
mellitus should be screened for PCOS," she said.
Treating PCOS can ease many of its
symptoms, said Cohen, who has no ties to the new research.
In adolescents, the first line of
treatment for PCOS is usually a combined oral contraceptive pill, she said.
"If the excessive hair growth doesn't improve, an anti-androgen medication
may be added," Cohen said.
When a child with PCOS is also overweight or obese, lifestyle modifications such as diet and exercise are recommended. "Sometimes a medication called metformin is used if there is prediabetes or type 2 diabetes," Cohen explained.